Fusogenic potential of sperm membrane lipids: Nature's wisdom to accomplish targeted gene delivery

GRANT NUMBER DAMD 17 - 94 - J - 4398 TITLE : Targeted Gene Delivery to Accomplish Gene Therapy for Breast Cancer

Sperm-Hybrid Micromotor for Targeted Drug Delivery.

A sperm-driven micromotor is presented as a targeted drug delivery system, which is appealing to potentially treat diseases in the female reproductive tract. This system is demonstrated to be an efficient drug delivery vehicle by first loading a motile sperm cell with an anticancer drug (doxorubicin hydrochloride), guiding it magnetically, to an in vitro cultured tumor spheroid, and finally fre...

Mixed Monolayers of Phospholipids and Fusogenic Lipids

after 24h no further increases were noted. Table 1 summarizes the general distribution pattern, and the extent of incorporation of 99Mo into protein in male mice after 2 days of oral administration. In a preliminary survey no sexual dimorphism was found. The duodenum had the highest degree of 99Mo incorporation and enzyme activity. Table 1 also shows the corresponding pattern for Drosophila lar...

Virulence Potential of Fusogenic Orthoreoviruses

Several severe respiratory virus infections that have emerged during the past decade originated in animals, including bats. In Indonesia, exposure to bats has been associated with increased risk of acquiring orthoreovirus infection. Although orthoreovirus infections are mild and self-limiting, we explored their potential for evolution into a more virulent form. We used conventional virus cultur...

Fluorescent lipids: functional parts of fusogenic liposomes and tools for cell membrane labeling and visualization.

In this paper a rapid and highly efficient method for controlled incorporation of fluorescent lipids into living mammalian cells is introduced. Here, the fluorescent molecules have two consecutive functions: First, they trigger rapid membrane fusion between cellular plasma membranes and the lipid bilayers of their carrier particles, so called fusogenic liposomes, and second, after insertion int...